Two-Layer Error Control Codes Combining Rectangular and Hamming Product Codes for Cache Error

We propose a novel two-layer error control code, combining error detection capability of rectangular codes and error correction capability of Hamming product codes in an efficient way, in order to increase cache error resilience for many core systems, while maintaining low power, area and latency overhead. Based on the fact of low latency and overhead of rectangular codes and high error control capability of Hamming product codes, two-layer error control codes employ simple rectangular codes for each cache line to detect cache errors, while loading the extra Hamming product code checks bits in the case of error detection; thus enabling reliable large-scale cache operations. Analysis and experiments are conducted to evaluate the cache fault-tolerant capability of various existing solutions and the proposed approach. The results show that the proposed approach can significantly increase Mean-Error-To-Failure (METF) and Mean-Time-To-failure (MTTF) up to 2.8×, reduce storage overhead by over 57%, and increase instruction per-cycle (IPC) up to 7%, compared to complex four-way 4EC5ED; and it increases METF and MTTF up to 133×, reduces storage overhead by over 11%, and achieves a similar IPC compared to simple eight-way single-error correcting double-error detecting (SECDED). The cost of the proposed approach is no more than 4% external memory access overhead

Robust Optimization With Applications In Healthcare Operations Management

Ph.DDOCTOR OF PHILOSOPH

trans-4,5-Dihydr­oxy-1,3-diphenyl­imidazolidine-2-thione

In the title compound, C15H14N2O2S, the five-membered ring adopts an envelope conformation and the two hydr­oxy groups lie on opposite sides of the ring. The six-membered rings are oriented at a dihedral angle of 22.63 (3)°. In the crystal structure, inter­molecular O—H⋯S and O—H⋯O hydrogen bonds link the mol­ecules into a two-dimensional network

Composite cathode based on yttria stabilized bismuth oxide for low-temperature solid oxide fuel cells

The investigation of composite cathodes consisting of silver and yttria stabilized bismuth oxide (YSB) for low-temperature honeycomb solid oxide fuel cells with stabilized zirconia as electrolyte was presented. The interfacial polarization resistances of a porous YSN-Ag cathode was about 0.3 ?? cm 2 at 600?? C. It was found by impedance analysis that the performance of an YSB-Ag composite cathode fired at 850?? C for 2 H was severely limited by gas transport due to insufficient porosity.open464

The Relationship Between Earnings Quality and Corporate Governance of Software and Information Technology Service Industry in China

With the development of China's capital market, many listed companies have emerged, especially the development of software and information technology industry. Therefore, the earnings information disclosed by enterprises and the earnings quality of enterprises are very important because it is the basis that investors can refer to when investing. At the same time, effective corporate governance is conducive to establish a reasonable and scientific company strategic decision making, implementation and supervision system. Therefore, the purpose of this paper is to research and analyse the relationship between earnings quality and corporate governance in China's software and information technology (IT) service industry. This paper selects the data of 259 enterprises from 2017 to 2019 as the sample, takes the absolute value of discretionary accruals as the dependent variable and the larger the value, the lower the earnings quality. Then, selecting 7 independent variables related to corporate governance to construct the model. Then, selecting appropriate regression method after the correlation test and test whether the model has autocorrelation and heteroscedasticity. It is concluded that that only two corporate governance variables are the decisive factors. Firstly, supervisory board size is positively related with earnings quality and significant at 0.05 level. Similarly, executive size also positively correlated with earnings quality and significant at 0.01 level. Although the board size, board independence and top three compensation are positive to earnings quality, they are not significant. Similarly, frequency of board meeting and duality of chairman and CEO are negative to earnings quality, but they are insignificant. Keywords: Earnings quality, corporate governanc

Effect and degradation pathway of sulfamethoxazole removal in MBR by PVDF/DA modified membrane

To reduce the hazard of sulfamethoxazole (SMX) to the water ecology, the removal mechanism of SMX in wastewater was revealed. This study evaluated the PVDF/DA modified membrane in the membrane bioreactor (MBR) toward the removal and degradation of SMX as a recalcitrant micropollutant. A strategy of dopamine for surface modification of polyvinylidene fluoride (PVDF) membrane was proposed, and PVDF/DA membrane was prepared. Subsequently, PVDF/DA was run in the MBR for 60 days, and the reactor could produce good removal ability for SMX after certain acclimation. When the SMX concentration increased from 0.5 to 2 mg/L, liquid chromatography was used for analysis, and the results showed that the average removal rate was above 85%. The removal effect of COD and NH4+-N and the degree of membrane fouling were also evaluated. By measuring the extracellular polymer (EPS) content, the results showed that after 30 days of operation, the protein and polysaccharide contents in the cake layer on the surface of the PVDF membrane were 1.35 times and 1.49 times that of PVDF/DA membrane, respectively, and the PVDF/DA membrane could alleviate membrane fouling, thereby improving the service life of the membrane and reducing its operating cost. Finally, degradation by-products are evaluated to achieve deeper insight into the degradation mechanisms in the MBR process

The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver diseases

Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological abnormalities and is characterized by significant and excessive accumulation of triglycerides in the hepatocytes in patients without alcohol consumption or other diseases. Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. Peroxisome proliferator-activated receptors (PPARs) are among the potential targets and have been demonstrated to exert a pivotal role in modulation of NAFLD. Many drugs developed so far are targeted at PPARs. Thus, the aim of this paper is to summarize the roles of PPARs in the treatment of NAFLD

Streptococcus suis 2 Transcriptional Regulator TstS Stimulates Cytokine Production and Bacteremia to Promote Streptococcal Toxic Shock-Like Syndrome

Two large-scale outbreaks of streptococcal toxic shock-like syndrome (STSLS) have revealed Streptococcus suis 2 to be a severe and evolving human pathogen. We investigated the mechanism by which S. suis 2 causes STSLS. The transcript abundance of the transcriptional regulator gene tstS was found to be upregulated during experimental infection. Compared with the wild-type 05ZY strain, a tstS deletion mutant (ΔtstS) elicited reduced cytokine secretion in macrophages. In a murine infection model, tstS deletion resulted in decreased virulence and bacterial load, and affected cytokine production. Moreover, TstS expression in the P1/7 strain of S. suis led to the induction of STSLS in the infected mice. This is noteworthy because, although it is virulent, the P1/7 strain does not normally induce STSLS. Through a microarray-based comparative transcriptomics analysis, we found that TstS regulates multiple metabolism-related genes and several virulence-related genes associated with immune evasion

Immunoproteomic analysis of outer membrane proteins and extracellular proteins of Actinobacillus pleuropneumoniae JL03 serotype 3

<p>Abstract</p> <p>Background</p> <p><it>Actinobacillus pleuropneumoniae </it>is the causative agent of porcine contagious pleuropneumonia, a highly contagious respiratory infection in pigs, and all the 15 serotypes are able to cause disease. Current vaccines including subunit vaccines could not provide satisfactory protection against <it>A. pleuropneumoniae</it>. In this study, the immunoproteomic approach was applied to the analysis of extracellular and outer membrane proteins of <it>A. pleuropneumoniae </it>JL03 serotype 3 for the identification of novel immunogenic proteins for <it>A. pleuropneumoniae</it>.</p> <p>Results</p> <p>A total of 30 immunogenic proteins were identified from outer membrane and extracellular proteins of JL03 serotype 3, of which 6 were known antigens and 24 were novel immunogenic proteins for <it>A. pleuropneumoniae</it>.</p> <p>Conclusion</p> <p>These data provide information about novel immunogenic proteins for <it>A. pleuropneumoniae </it>serotype 3, and are expected to aid in development of novel vaccines against <it>A. pleuropneumoniae</it>.</p